Brief Definitive Report Inhibition of the Fc Receptor of Human Lymphoid Cells by Antisera- Recognizing Determinants of the Hla System* the Journal of Experimental Medicine @bullet Volume
نویسندگان
چکیده
B lymphocytes are equipped with a receptor for the recognition of the Fc part of IgG (1, 2) which is not identical to the surface Ig receptor (3). Dickler and Sachs (4) found that anti-Ia antibodies inhibit the binding of aggregated IgG to this receptor, whereas anti-H2D or K antibodies did not have the same effect. On the other hand, Schirrmacher et al. (5) found that also antibodies against other B-lymphocyte surface constituents than Ia could interfere with the Fc receptor. However, the Ia antigens are probably not part of the Fc receptor molecule (6), and the observed inhibition may best be explained by a close association between Fc receptors and the Ia antigens in the B-cell membrane. Since Ia antibodies do not inhibit the Fc receptors of macrophages or fetal liver cells (7), the association between Ia and Fc on these cells may be less pronounced.
منابع مشابه
Inhibition of the Fc receptor of human lymphoid cells by antisera- recognizing determinants of the hla system
The inhibitory effect of HLA antisera on Fc receptors of human lymphoid cells was investigated. The ability of lymphoid cells to form rosettes (FcRFC) with antibody-coated sheep red blood cells and to function as effector cells (K cells) in antibody-dependent cell-mediated cytotoxicity were used as assay systems. We found that antisera recognizing determinants of the HLA-A, -B, and -C series ha...
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